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Official publication of the Indian Society of Nephrology
 
CASE REPORT
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Circulating monoclonal IgG1-kappa antibodies causing anti-glomerular basement membrane nephritis


1 Department of Nephropathology, Manipal Hospital, Bengaluru, Karnataka, India
2 Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
3 Department of Nephrology, NU Hospitals, Bengaluru, Karnataka, India

Correspondence Address:
M Vankalakunti,
Department of Nephropathology, Manipal Hospital, Rustom Bagh, Bengaluru - 560 017, Karnataka
India
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Source of Support: None, Conflict of Interest: None

Anti-glomerular basement membrane (GBM) antibody disease is a rare but well-characterized cause of glomerulonephritis. Patients present with rapidly progressive renal failure with hemoptysis. Early diagnosis is crucial in salvaging the renal damage and life-threatening pulmonary hemorrhage. Plasmapheresis and immunosuppression is the mode of therapy. Anti-GBM antibodies are polyclonal in nature. However, rare monoclonal antibodies can cause similar destruction of glomerular capillary walls. We describe distinct combination of circulating monoclonal and anti-GBM nephritis.


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    -  Vankalakunti M
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Indian Journal of Nephrology
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Online since 20th Sept '07