Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Author Reply
Book Review
Brief Communication
Case Report
Case Series
Clinical Case Report
Clinicopathological Conference
Commentary
Corrigendum
Editorial
Editorial – World Kidney Day 2016
Editorial Commentary
Erratum
Foreward
Guidelines
Image in Nephrology
Images in Nephrology
Letter to Editor
Letter to the Editor
Letters to Editor
Literature Review
Notice of Retraction
Obituary
Original Article
Perspective
Research Letter
Retraction Notice
Review
Review Article
Short Review
Special Article
Special Feature
Special Feature - World Kidney Day
Systematic Review
Technical Note
Varia
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Author Reply
Book Review
Brief Communication
Case Report
Case Series
Clinical Case Report
Clinicopathological Conference
Commentary
Corrigendum
Editorial
Editorial – World Kidney Day 2016
Editorial Commentary
Erratum
Foreward
Guidelines
Image in Nephrology
Images in Nephrology
Letter to Editor
Letter to the Editor
Letters to Editor
Literature Review
Notice of Retraction
Obituary
Original Article
Perspective
Research Letter
Retraction Notice
Review
Review Article
Short Review
Special Article
Special Feature
Special Feature - World Kidney Day
Systematic Review
Technical Note
Varia
View/Download PDF

Translate this page into:

Letter to Editor
20 (
2
); 118-119
doi:
10.4103/0971-4065.65313

ACE polymorphism and diabetic nephropathy

Wiwanitkit House, Bangkhae, Bangkok, Thailand - 101 60
Address for correspondence: Prof. V. Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok, Thailand - 101 60. E-mail: wviroj@yahoo.com
Licence

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Disclaimer:
This article was originally published by Medknow Publications and was migrated to Scientific Scholar after the change of Publisher.

Sir,

I read with great interest the recent report by Naresh et al.[1] Naresh et al. finally suggested an association of DD polymorphism and type II diabetes with nephropathy."[1] Indeed, angiotensin converting enzyme (ACE) polymorphism is a classical, widely studied genetic polymorphism. It is confirmed that ACE polymorphism is correlated to the progression on renal disease.[2] However, there are some interesting notes for the present work. First, it should be noted that the genetic polymorphism is a genetic topic to be talked about on a population scale. A common limitation of genetic polymorphism is the limitation in the number of subjects. Second, race might have a significant effect on the pattern of ACE polymorphism.[3] This data should be clarified and assessed. Finally, it should also be cited that the recent data on metaanalysis for the correlation between ACE polymorphism and diabetic retinopathy, another common diabetic complication, showed null correlation.[4]

References

  1. , , , , , , . Angiotensin converting enzyme gene polymorphism in type II diabetics with nephropathy. Indian J Nephrol. 2009;19:145-8.
    [Google Scholar]
  2. , . Angiotensin-converting enzyme gene polymorphism: I and D alleles from some different countries. Clin Appl Thromb Hemost. 2004;10:179-82.
    [Google Scholar]
  3. , . Angiotensin-converting enzyme gene polymorphism is correlated to the progression of disease in patients with IgA nephropathy: a meta-analysis. Ren Fail. 2006;28:697-9.
    [Google Scholar]
  4. , . Angiotensin-converting enzyme gene polymorphism is correlated to diabetic retinopathy: a meta-analysis. J Diabetes Complications. 2008;22:144-6.
    [Google Scholar]

Fulltext Views
59

PDF downloads
30
View/Download PDF
Download Citations
BibTeX
RIS
Show Sections