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Year : 2007  |  Volume : 17  |  Issue : 2  |  Page : 68-69

Sirolimus-induced pneumonitis

Departments of Nephrology and Pulmonology, Army Hospital (R and R), Delhi Cantt, New Delhi, India

Correspondence Address:
P P Varma
Department of Nephrology, Army Hospital (R and R), Delhi Cantt, New Delhi - 110 010
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.37024

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Rapamycin is increasingly being used as calcineurin-inhibitor-sparing immunosuppressive drug. We report a case who presented with fever, breathlessness and bilateral crackles in the chest 6 weeks after administering rapamycin. Chest skiagram showed right-sided pneumonitis and bronchoalveolar lavage was negative for infective pathogens. He did not respond to antibiotics; while administering antibiotics, he also developed left-sided pneumonitis. Rapamycin withdrawal promptly brought clinical and radiological response.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07