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Year : 2007  |  Volume : 17  |  Issue : 2  |  Page : 73-75

Propylthiouracil-associated antineutrophil cytoplasmic antibody positive crescentic glomerulonephritis

Manipal Institute of Nephrology and Urology, Manipal Hospital, Bangalore, Karnataka, India

Correspondence Address:
S Ballal
Manipal Institute of Nephrology and Urology, Manipal Hospital, # 98, Rustom Bagh, Airport Road, Bangalore - 560 017, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.37026

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The vasculitic syndromes of Wegeners granulomatosis, microscopic polyangitis, Churg-Strauss syndrome and renal limited variants are associated with antineutrophil cytoplasmic antibodies (ANCA). Positive ANCA are also seen in many viral infections, inflammatory bowel diseases and drugs. Drug-induced ANCA-associated renal disease is reported less frequently than drug-induced lupus nephritis. ANCA-positive crescentic glomerulonephritis due to propylthiouracil has been reported in children and adults especially in Japanese population. The renal outcome is better in propylthiouracil-associated ANCA-positive crescentic GN as compared with nondrug-induced crescentic GN. Propylthiouracil-associated ANCA-positive crescentic GN may or may not require steroid and cytotoxic therapy depending on the severity of renal failure. We report a case of propylthiouracil-associated ANCA-positive crescentic GN with severe renal failure; the renal function improved after steroid and cytotoxic therapy.


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Indian Journal of Nephrology
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Online since 20th Sept '07