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Year : 2007  |  Volume : 17  |  Issue : 4  |  Page : 182-184

Growth hormone therapy in chronic kidney disease

1 Department of Endocrinology and Metabolism, Medwin Hospital, Hyderabad, India
2 Department of Nephrology, Medwin Hospital, Hyderabad, India

Correspondence Address:
R Jha
Medwin Hospitals, Chirag Ali Lane, Abids, Hyderabad - 500 001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.39176

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Chronic kidney disease (CKD) in growing children leads to a state of impaired growth due to altered metabolic status and defective growth hormone action. This requires direct intervention over and above the management of the renal disease. The physical deficit of short stature has significant impact on the psychological well-being and quality of life. With increasing availability of recombinant human growth hormone (GH) and its approval in CKD patients with significant short stature, it has been increasingly used in short children with CKD. GH therapy in these patients has significantly improved the final adult height achieved. Two prepubertal children with CKD and severe short stature who were treated with GH for approximately 2 years achieved significant growth benefits and one of them attained satisfactory adult height.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07