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Year : 2008  |  Volume : 18  |  Issue : 2  |  Page : 51-57

Prophylactic effects of wormwood on lipid peroxidation in an animal model of lead intoxication

Department of Biology, Faculty of Science; Laboratory of Biochemistry. University of Es-senia, Oran, Algeria

Correspondence Address:
O Kharoubi
Department of Biology, Faculty of Science; Laboratory of Biochemistry. B.P. 19, University of Es-senia, Oran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.42333

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The ability of Wormwood ( Artemisia absinthium L.) extract (A.Ab) to restore membrane-bound enzymes like Na+-K+-ATPase, Ca++-ATPase, Mg++-ATPase, and oxidative damage induced by lead were investigated. Rats were exposed to lead acetate (750 ppm) for 11-weeks and treated during 4-weeks with A.Ab. Lipid levels, ATPase activity, thiobarbituric acid reactive substances (TBARS), and proteins carbonyl were estimated. In liver and kidney, lead acetate inhibited membrane-bound enzymes and increased ( P < 0.05) the levels of cholesterol, triglycerides, free fatty acids, phospholipids, TBARS, and carbonyl proteins. After 4 weeks, the intoxicated group who received A.Ab showed a significant reduction in TBARS and carbonyl levels in liver and kidney compared to group exposed to lead. A.Ab restored the levels of membrane-bound enzymes and lipid levels to near normal. These results indicate that aqueous Wormwood extract had a significant antioxidant activity and protect liver and kidney from the lead-induced toxicity.


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Indian Journal of Nephrology
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Online since 20th Sept '07