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Year : 2008  |  Volume : 18  |  Issue : 2  |  Page : 64-69

Thickness of glomerular and tubular basement membranes in preclinical and clinical stages of diabetic nephropathy

1 Institute of Pathology, ICMR, Post Box 4909, India
2 Safdarjung Hospital, New Delhi- 110 029, India

Correspondence Address:
S Saxena
Institute of Pathology, ICMR, Post Box 4909, New Delhi- 110 029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.42336

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Aims: This study aimed to elucidate the early renal changes in diabetes mellitus (DM) with and without clinical symptoms related to renal damage. Methods: Renal biopsy was studied in 25 patients (14 with microalbuminuria and 11 with albuminuria) both by light and electron microscopies (LM and EM, respectively) for renal changes and morphometry was performed to study glomerular and tubular basement membranes (GBM and TBM, respectively) width using a Soft Imaging System GmBH (analysis 3). Results: A significant increase was noted in the mean GBM and TBM thickness in both the preclinical and clinical groups compared to the control group. The changes in the TBM were noted to be predominant in both preclinical and clinical patients. Conclusions: This study indicates the importance of morphometric evaluation of the GBM and TBM width in the elucidation of early renal damage in diabetic nephropathy, especially in the absence of LM changes. The significance of identification of early renal changes using morphometric techniques for better management of these patients requires further studies.


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Indian Journal of Nephrology
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Online since 20th Sept '07