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Year : 2010  |  Volume : 20  |  Issue : 3  |  Page : 142-145

Sildenafil citrate can improve erectile dysfunction among chronic hemodialysis patients

Department of Internal Medicine, Urmia University of Medical Sciences, Imam Khomeini Training Hospital, Urmia, Iran

Correspondence Address:
N Sepehrvand
Students' Research Committee, Deputy for Research Affairs, Urmia University of Medical Sciences, Resalat Avenue, Djahad Square, Urmia
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Source of Support: Urmia University of Medical Sciences (UMSU), Conflict of Interest: None

DOI: 10.4103/0971-4065.70845

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Erectile dysfunction (ED) is common among patients with end-stage renal disease (ESRD), who undergo hemodialysis (HD). The aim of this study was to evaluate the safety and effectiveness of sildenafil in male HD patients with ED. Twenty-seven HD patients were recruited for this prospective, randomized, double-blind, placebo-controlled, clinical trial study of sildenafil during a period of 1 week. Efficacy was assessed by using the International Index of Erectile Function (IIEF) before and 1 week after treatment. Baseline demographic and clinical features were similar in both the groups. There was a weak correlation between ED and duration of undergoing dialysis (P = 0.073). There was significant relationship between sildenafil usage and improvement in erectile function (P < 0.0001). Placebo improved significantly the erectile function (P = 0.016), perhaps by psychological way. However, sildenafil had a more significant effect than placebo in increasing IIEF score among HD patients (P = 0.00 compared to 0.016). Sildenafil is effective and safe for treating ED among HD patients.


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Indian Journal of Nephrology
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Online since 20th Sept '07