| CASE REPORT |
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| Year : 2011 | Volume
: 21
| Issue : 3 | Page : 194-197 |
Prerenal azotemia from excessive sweating in an adult with a cystic fibrosis gene mutation
SV Tomov1, PA Flume2, AE Stenbit2, ME Ullian1
1 Department of Medicine, Divisions of Nephrology, Medical University of South Carolina, South Carolina, USA
2 Department of Pulmonology, Medical University of South Carolina, South Carolina, USA
Correspondence Address:
M E Ullian
Department of Medicine, Division of Nephrology, Medical University of South Carolina, 96 Jonathan Lucas Street, MSC629 Charleston, South Carolina 29425-6290
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0971-4065.82637
We present the case of a 58-year-old male with chronic kidney disease who was admitted to the hospital multiple times with extracellular fluid volume depletion and prerenal azotemia. Some episodes were associated with gastrointestinal fluid losses and others with profuse diaphoresis in the absence of gastrointestinal fluid losses. At the age of 57 years, a common cystic fibrosis transmembrane conductance regulator protein mutation and a family history of cystic fibrosis were documented. We hypothesize that the abnormal cystic fibrosis transmembrane conductance regulator resulted in repeated bouts of excessive sweating, extracellular fluid volume depletion, and acute renal failure. This case is unique because of the prolonged period of time over which multiple documented episodes of prerenal acute renal failure occurred and because of the onset of the episodes in adulthood.
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