Recombinant activated factor VII for diffuse alveolar hemorrhage in microscopic polyangiitis

SK Mandal; G Sagar; M Sahoo; S Jasuja

doi:10.4103/0971-4065.97134

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CASE REPORT

Year : 2012 | Volume : 22 | Issue : 2 | Page : 130-132

Recombinant activated factor VII for diffuse alveolar hemorrhage in microscopic polyangiitis

SK Mandal, G Sagar, M Sahoo, S Jasuja
Department of Nephrology, Indraprastha Apollo Hospital, New Delhi, India

Correspondence Address:
S Jasuja
Department of Nephrology, Indraprastha Apollo Hospital, New Delhi
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0971-4065.97134

Diffuse alveolar hemorrhage is a serious complication of the small vessel vasculitis syndromes and carries a high mortality. Recombinant activated factor VII (rFVIIa) is a powerful hemostatic agent developed for treatment of bleeding in patients with hemophilia and antibodies to factors VIII or IX. It has been used increasingly in life-threatening hemorrhage in a variety of other settings in which conventional medical or surgical therapy is unsuccessful. We report the successful use of rFVIIa for massive pulmonary hemorrhage in a patient of microscopic polyangiitis, which was later complicated by thrombotic microangiopathy and posterior reversible encephalopathy syndrome.

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