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Year : 2012  |  Volume : 22  |  Issue : 3  |  Page : 210-212

Baclofen-induced encephalopathy in patient with end stage renal disease: Two case reports

1 Department of Nephrology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Chemistry, Islamic Azad University, Omidiyeh Branch, Omidiyeh, Iran

Correspondence Address:
S S Beladi Mousavi
Department of Nephrology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahva
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.98762

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We report two end stage renal disease (ESRD) patients, who rapidly developed neurotoxicity after taking baclofen, a centrally acting gamma-aminobutyric acid agonist. They presented to our hospital in a state of confusion. On physical examination, there were no focal neurological deficits and the remainder of the examination was also not diagnostic. Laboratory data were unremarkable. The consciousness improved with supportive treatment and intensive hemodialysis over 3-4 days. In conclusion, physicians should be aware of the possibility of baclofen-induced neurotoxicity in patients with renal disease, especially in ESRD patients and it is necessary to avoid or reduce baclofen dosage in these patients.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07