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Year : 2012  |  Volume : 22  |  Issue : 3  |  Page : 213-216

Diffuse mesangial sclerosis Report of two cases

1 Department of Pathology, Manipal Hospital, Bangalore, India
2 Department of Nephrology, Manipal Hospital, Bangalore, India
3 Department of Nephrology, Vaatsalya Hospital, Bijapur, India

Correspondence Address:
M Vankalakunti
Consultant Pathologist, Pathology and Laboratory Medicine; Manipal Hospital, Bangalore
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.98764

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Diffuse mesangial sclerosis (DMS) is a rare cause of nephrotic syndrome in the infantile and childhood period. DMS is a phenotypic expression of syndromic entities such as WAGR syndrome (Wilms' tumor, aniridia, genitourinary anomalies and mental retardation), Denys Drash syndrome, Pierson syndrome, Frasier syndrome, or Galloway-Mowat syndrome. We report two cases of DMS, one presenting in first year of life and another in second decade of life. Both of them had fatal outcome. Recognition of the disease is very important in modifying the management of patient and active surveillance of family members.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07