|
 |
| LETTER TO EDITOR |
|
|
|
| Year : 2012 | Volume
: 22
| Issue : 3 | Page : 231-232 |
| |
Collapsing glomerulopathy: The Indian scenario
KP Malhotra, S Sharma
Department of Pathology, University College of Medical Sciences, Dilshad Garden, Delhi, India
| Date of Web Publication | 20-Jul-2012 |
Correspondence Address:
K P Malhotra
Department of Pathology, University College of Medical Sciences, Delhi 110 095
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0971-4065.98790
How to cite this article:
Malhotra K P, Sharma S. Collapsing glomerulopathy: The Indian scenario. Indian J Nephrol 2012;22:231-2 |
Sir,
We read with interest the case report by Naaz et al. describing the first case of collapsing glomerulopathy in an HIV positive patient in Kashmir. [1] This lesion is being increasingly diagnosed by nephropathologists at other centers in India, with increasing awareness of the morphologic changes. [2],[3],[4] With reference to the above, we would like to mention that collapsing glomerulopathy is the commonest renal lesion associated with HIV; however, it is not HIV alone that causes this pathomorphologic insult. This assortment of pathologic changes is also seen in association with a myriad of other illnesses, namely infections including cytomegalovirus, Hepatitis C virus, and pulmonary tuberculosis; autoimmune disorders such as Systemic Lupus and adult Still's disease; malignancies including multiple myeloma and myeloid leukemia and with the use of drugs including interferon and pamidronate. [5] An increasing number of cases are also being diagnosed post-renal transplantation. [4] Identification of the lesion should be an indication of severe renal injury regardless of the causative etiology. Consciousness of this entity will enhance its diagnosis in the near future.
| References | |  |
| 1. | Naaz I, Wani R, Najar MS, Banday K, Baba KM, Jeelani H. Collapsing glomerulopathy in an HIV-positive patient in a low-incidence belt. Ind J Nephrol 2010;20:211-3. 
[PUBMED] |
| 2. | Agrawal V, Vinod PB, Krishnani N, Sharma RK. A case of collapsing glomerulopathy associated with febrile illness. Indian J Pathol Microbiol 2008;51:509-11.
[PUBMED]  |
| 3. | Gupta R, Sharma A, Bhowmik D, Gupta S, Agarwal S, Gupta R, et al. Collapsing glomerulopathy occurring in HIV-negative patients with systemic lupus erythematosus: Report of three cases and brief review of the literature. Lupus 2011;20:866-70.
[PUBMED] |
| 4. | Gupta R, Sharma A, Agarwal SK, Dinda AK. Collapsing glomerulopathy in renal allograft biopsies: A study of nine cases. Indian J Nephrol 2011;21:10-3.
[PUBMED] |
| 5. | Albaqumi M, Soos TJ, Barisoni L, Nelson PJ. Collapsing glomerulopathy. J Am Soc Nephrol 2006;17:2854-63.
[PUBMED] |
|
|
Editorial Board
