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  Table of Contents  
Year : 2012  |  Volume : 22  |  Issue : 3  |  Page : 231-232

Collapsing glomerulopathy: The Indian scenario

Department of Pathology, University College of Medical Sciences, Dilshad Garden, Delhi, India

Date of Web Publication20-Jul-2012

Correspondence Address:
K P Malhotra
Department of Pathology, University College of Medical Sciences, Delhi 110 095
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.98790

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How to cite this article:
Malhotra K P, Sharma S. Collapsing glomerulopathy: The Indian scenario. Indian J Nephrol 2012;22:231-2

How to cite this URL:
Malhotra K P, Sharma S. Collapsing glomerulopathy: The Indian scenario. Indian J Nephrol [serial online] 2012 [cited 2022 Dec 5];22:231-2. Available from:


We read with interest the case report by Naaz et al. describing the first case of collapsing glomerulopathy in an HIV positive patient in Kashmir. [1] This lesion is being increasingly diagnosed by nephropathologists at other centers in India, with increasing awareness of the morphologic changes. [2],[3],[4] With reference to the above, we would like to mention that collapsing glomerulopathy is the commonest renal lesion associated with HIV; however, it is not HIV alone that causes this pathomorphologic insult. This assortment of pathologic changes is also seen in association with a myriad of other illnesses, namely infections including cytomegalovirus, Hepatitis C virus, and pulmonary tuberculosis; autoimmune disorders such as Systemic Lupus and adult Still's disease; malignancies including multiple myeloma and myeloid leukemia and with the use of drugs including interferon and pamidronate. [5] An increasing number of cases are also being diagnosed post-renal transplantation. [4] Identification of the lesion should be an indication of severe renal injury regardless of the causative etiology. Consciousness of this entity will enhance its diagnosis in the near future.

  References Top

1.Naaz I, Wani R, Najar MS, Banday K, Baba KM, Jeelani H. Collapsing glomerulopathy in an HIV-positive patient in a low-incidence belt. Ind J Nephrol 2010;20:211-3.  Back to cited text no. 1
2.Agrawal V, Vinod PB, Krishnani N, Sharma RK. A case of collapsing glomerulopathy associated with febrile illness. Indian J Pathol Microbiol 2008;51:509-11.  Back to cited text no. 2
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3.Gupta R, Sharma A, Bhowmik D, Gupta S, Agarwal S, Gupta R, et al. Collapsing glomerulopathy occurring in HIV-negative patients with systemic lupus erythematosus: Report of three cases and brief review of the literature. Lupus 2011;20:866-70.  Back to cited text no. 3
4.Gupta R, Sharma A, Agarwal SK, Dinda AK. Collapsing glomerulopathy in renal allograft biopsies: A study of nine cases. Indian J Nephrol 2011;21:10-3.  Back to cited text no. 4
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5.Albaqumi M, Soos TJ, Barisoni L, Nelson PJ. Collapsing glomerulopathy. J Am Soc Nephrol 2006;17:2854-63.  Back to cited text no. 5


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Indian Journal of Nephrology
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