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Year : 2012  |  Volume : 22  |  Issue : 6  |  Page : 409-414

Human leukocyte antigen antibody incompatible renal transplantation

1 Renal Unit, University Hospitals and Warwickshire NHS Trust, Coventry, United Kingdom
2 Renal Unit; Clinical Sciences and Research Institute, University Hospitals and Warwickshire NHS Trust, Coventry, United Kingdom
3 Department of Tissue Typing, National Health Service Blood and Transplant, Birmingham, United Kingdom

Correspondence Address:
N S Krishnan
University Hospitals Coventry and Warwickshire NHS Trust, Coventry
United Kingdom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.106029

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Anti-human leukocyte antigen (HLA) antibodies are recognized as an important problem in organ transplant recipients. This is because antibodies formed against a graft months or years after implantations are the major cause of late allograft failure, and also because protocols allow the transplantation of some grafts across pre-formed HLA antibodies. Advances in our understanding of anti-HLA antibody- mediated rejection (AMR) have occurred because of a better understanding of the histological findings during AMR; more sensitive and specific methods to measure anti-HLA antibodies; and through clinical investigation of patients transplanted across an HLA barrier. Despite advances in therapy and investigation, AMR remains a major problem and treatment protocols often fail to treat it successfully. This review aims to describe the issues in each of these areas and to suggest how clinicians may be able to improve the management of patients with anti-HLA antibodies.


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Indian Journal of Nephrology
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Online since 20th Sept '07