Indian Journal of Nephrology About us |  Subscription |  e-Alerts  | Feedback | Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Current Issue | Archives| Ahead of print | Search |Instructions |  Editorial Board  

Users Online:377

Official publication of the Indian Society of Nephrology
 ~  Similar in PUBMED
 ~  Search Pubmed for
 ~  Search in Google Scholar for
 ~  Article in PDF (378 KB)
 ~  Citation Manager
 ~  Access Statistics
 ~  Reader Comments
 ~  Email Alert *
 ~  Add to My List *
* Registration required (free)  

   Article Tables

 Article Access Statistics
    PDF Downloaded108    
    Comments [Add]    
    Cited by others 1    

Recommend this journal


  Table of Contents  
Year : 2014  |  Volume : 24  |  Issue : 2  |  Page : 127-128

Epidemiology of vitamin D deficiency in West African hemodialysis patients: A pilot study from Senegal

1 Department of Nephrology, Faculty of Health Sciences, Gaston Berger University, Saint-Louis, Senegal
2 Department of Biochemistry, Faculty of Health Sciences, Gaston Berger University, Saint-Louis, Senegal
3 Department of Nephrology, Aristide Le Dantec University Hospital, Plateau, Dakar, Senegal

Date of Web Publication27-Feb-2014

Correspondence Address:
S M Seck
Department of Nephrology, Faculty of Health Sciences, Gaston Berger University, Ngallele Road, BP 234, Saint-Louis
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.127913

Rights and Permissions

How to cite this article:
Seck S M, Cisse M M, Ka E F, Doupa D. Epidemiology of vitamin D deficiency in West African hemodialysis patients: A pilot study from Senegal. Indian J Nephrol 2014;24:127-8

How to cite this URL:
Seck S M, Cisse M M, Ka E F, Doupa D. Epidemiology of vitamin D deficiency in West African hemodialysis patients: A pilot study from Senegal. Indian J Nephrol [serial online] 2014 [cited 2022 Jun 30];24:127-8. Available from:


Vitamin D deficiency is common in chronic kidney disease patients undergoing hemodialysis and is associated with bone disorders [1] and increased mortality. [2] Previous studies suggest that vitamin D deficiency is more frequent in patients with an African origin whose skin pigmentation is a barrier to ultraviolet rays necessary to 25-OH vitamin D synthesis. [1],[3] Like in many developing regions, little is currently known about vitamin D status of dialysis patients from Sub-Saharan Africa. [4] Data from black populations living in the United States or Europe might not be applicable for African patients whose dietary habits and sunlight exposures are different. We report here a pilot study that aimed to determine the prevalence of vitamin D deficiency in Senegalese hemodialysis patients.

In a cross-sectional study between March 30 th and October 30 th 2011, we included 46 patients from two main hemodialysis centers in Dakar. Clinical data, serum calcium, phosphate and vitamin D levels during the last 3 months were collected from patients'medical records. All dosages of 25-OH vitamin D were performed using electrochemiluminescence immunoassay (COBAS Roche Diagnostics). Vitamin D deficiency was defined as a serum 25-OH vitamin D level <15 μg/l. Univariate and multivariate logistic regressions were used to identify the factors associated with vitamin D deficiency.

Mean age of patients was 50.3 ± 12.7 years (13-77 years) and 39.1% of them were females. All patients were dialyzed using the bicarbonate buffer and a calcium rich dialysate (1.75 mmol/l). Almost all of them (91%) had a weekly Kt/V >1.2. Thirty six patients (78.2%) presented pre-dialysis high blood pressure (≥140/90 mmHg) and six patients (13%) had a body mass index above 30 kg/m 2 . The etiologies of end-stage renal disease were dominated by hypertension (39%) and diabetes (26%).

Prevalence of vitamin D deficiency was 32.6% and 28 patients (60.8%) had a vitamin D level between 15 μg/Land 30 μg/l). This prevalence was comparable between men and women (respectively 47.3% and 50.0%, P = 0.93). After multivariate logistic regression, age ≥50 years, hypocalcemia and hyperparathyroidism showed significant association of vitamin D deficiency, but gender and hyperphosphatemia did not [Table 1].

The present results show that the prevalence of vitamin D deficiency in hemodialysis patients living in Senegal is similar to those reported in Western countries. [1],[3],[5]
Table 1: Parameters associated with vitamin D deficiency

Click here to view

Despite limitation due to small sample size and the cross-sectional study design, this study could be a basis for larger prospective cohort that would also assess the effect of vitamin D deficiency on bone and cardiovascular outcomes in African dialysis patients.

  References Top

1.Ureña-Torres P, Metzger M, Haymann JP, Karras A, Boffa JJ, Flamant M, et al. Association of kidney function, vitamin D deficiency, and circulating markers of mineral and bone disorders in CKD. Am J Kidney Dis 2011;58:544-53.  Back to cited text no. 1
2.Pilz S, Iodice S, Zittermann A, Grant WB, Gandini S. Vitamin D status and mortality risk in CKD: Ameta-analysis of prospective studies. Am J Kidney Dis 2011;58:374-82.  Back to cited text no. 2
3.Bhan I, Powe CE, Berg AH, Ankers E, Wenger JB, Karumanchi SA, et al. Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney Int 2012;82:84-9.  Back to cited text no. 3
4.Seck SM, Dahaba M, Ka EF, Cisse MM, Gueye S, Tal AO. Mineral and bone disease in black African hemodialysis patients: A report from Senegal. Nephrourol Mon 2012;4:613-6.  Back to cited text no. 4
5.Jean G, Charra B, Chazot C. Vitamin D deficiency and associated factors in hemodialysis patients. J Ren Nutr 2008;18:395-9.  Back to cited text no. 5


  [Table 1]

This article has been cited by
1 Mineral bone disorder and osteoporosis in hemodialysis patients
Maroua Slouma, Hela Sahli, Afef Bahlous, Lilia Laadhar, Wided Smaoui, Sonia Rekik, Imen Gharsallah, Meriem Sallami, Fatma Ben Moussa, Mohamed Elleuch, Elhem Cheour
Advances in Rheumatology. 2020; 60(1)
[Pubmed] | [DOI]


Print this article  Email this article


Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07