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Year : 2014  |  Volume : 24  |  Issue : 3  |  Page : 166-170

Differences among children, adolescents and adults with severe leptospirosis: A comparative analysis

1 Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil
2 Department of Nephrology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
3 Department of Community Health, School of Medicine, Federal University of Ceará; Department of Infectious Diseases, São José Infectious Diseases Hospital, Fortaleza, Ceará, Brazil
4 Department of Internal Medicine, School of Medicine, Federal University of Ceará; Department of Medicine, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil

Correspondence Address:
E F Daher
Rua Vicente Linhares, 1198, Fortaleza, CE, CEP: 60135-270
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.132013

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Leptospirosis is a zoonosis of global importance caused by Leptospira interrogans. The aim of this study was to compare the data between children, adolescents and adults with leptospirosis. This is a retrospective study including a total of 373 consecutive patients with leptospirosis, admitted to tertiary hospitals in Northeast of Brazil, from May 1985 to August 2010. The patients were divided into two groups (age ≤21 years and >21 years). The adults were 304 (81.5%) of the population, with a mean ge of 41 ± 13 (range 22-84) years. The pediatric group was 16 ± 3 (range 9-21) years. Signs and symptoms where similar between the groups, excepting arrhythmia, which was more frequent in adults and vomiting, more common in children (16% vs. 0%, P = 0.04 and 65% vs. 79%, P = 0.02), respectively. Adult group presented with higher serum urea (137 vs. 97 mg/dl, P = 0.002) and creatinine (4.3 vs. 3.0 mg/dl, P = 0.007). Acute kidney injury (AKI) was observed in 80%, mainly in adults (83% vs. 70% P < 0.005). Adults required renal replacement therapy more frequently than children (38% vs. 11%, P < 0.0001). Mortality was higher in adults (14.8% vs. 2.8%, P = 0.005) and in adults with AKI (93% vs. 7%, P < 0.05). There are important differences between the adults and children with leptospirosis. AKI was more frequent in adults and it was associated with increased mortality.


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