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Year : 2014  |  Volume : 24  |  Issue : 5  |  Page : 302-307

Mineral bone disease in maintenance hemodialysis patients: Association with morbidity and mortality

1 Department of Nephrology, Madras Medical Mission Hospital and TANKER Foundation, Chennai, India
2 Department of Nephrology, Madras Medical Mission Hospital and TANKER Foundation, Chennai; Department of Medicine, Pondicherry Institute of Medical Sciences, Puducherry, Tamil Nadu, India

Correspondence Address:
G Abraham
9/2, 15th Avenue, Harrington Road, Chetpet, Chennai - 600 031, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.132988

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There is a paucity of data on mineral bone disease in maintenance hemodialysis (MHD) patients from India. This retrospective analysis was undertaken on 858 (males: 599; females: 259) patients from two medical centers on MHD from 1998 to 2010. Age, gender, months on dialysis, hours per session of dialysis, hemoglobin, serum calcium, inorganic phosphorus, intact parathyroid hormone (iPTH), urine output, erythropoietin dosage per week, blood sugar, blood pressure, urea reduction rate, gain in fluid and fluid removed per session, serum albumin, alkaline phosphatase, vitamin D level, supplemental vitamin D and use of phosphate binder for therapy were documented. Overall, 191 patients died (22%) during the observation period. There was an 86% patient survival rate at 1 year on dialysis and an overall predicted 3-year survival rate of 78%. A relatively higher iPTH (P = 0.012), a need for vitamin D supplementation (P = 0.003), less hours on dialysis per session (P = 0.046) and a non-vegetarian diet (P = 0.022) were significantly associated with mortality.


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Indian Journal of Nephrology
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Online since 20th Sept '07