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Year : 2014  |  Volume : 24  |  Issue : 6  |  Page : 339-348

Current concepts in C3 glomerulopathy


1 Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia
2 Department of Pathology, Royal Brisbane and Women's Hospital, Brisbane, Australia
3 Department of Renal Medicine, Hervey Bay Hospital, Hervey Bay, Australia

Correspondence Address:
G T John
Department of Renal Medicine, Level 9, Ned Hanlon Building, Royal Brisbane and Women's Hospital, Herston QLD 4029
Australia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.134089

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Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising of dense deposit disease and C3 glomerulonephritis. The key histological feature is the presence of isolated C3 deposits without immunoglobulins. Often masqueradng as some of the common glomerulonephritides this is a prototype disorder occurring from dysregulated alternate complement pathway with recently identified genetic defects and autoantibodies. We review the pathophysiology, clinical features, and diagnostic and treatment strategies.






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Indian Journal of Nephrology
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Online since 20th Sept '07