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Year : 2014  |  Volume : 24  |  Issue : 6  |  Page : 376-379

Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature

1 Department of Nephrology, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India
2 Department of Histopathology, Apollo Hospitals, Hyderabad, Andhra Pradesh, India

Correspondence Address:
R Jha
Department of Nephrology, Medwin Hospital, Nampally, Hyderabad - 500 001, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.133012

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Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a newly recognized entity caused by monoclonal deposition of IgG. PGNMID resembles immune complex glomerulonephritis (GN) on light and electron microscopy. The monotypic immunoglobulin deposits seen on immunofluorescence (IF) clinches the diagnosis. We report a case of proliferative GN associated MGRS and review the relevant literature. The patient had significant proteinuria and elevated serum creatinine. The renal biopsy showed proliferative GN with focal crescents and monoclonal immune deposits confirming a diagnosis of PGNMID. Serum work up showed no monoclonal proteins. Proliferative GN as a manifestation of a monoclonal gammopathy needs to be borne in mind especially in renal biopsies of older patients.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07