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Year : 2015  |  Volume : 25  |  Issue : 2  |  Page : 82-85

Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?

1 Department of Anatomical Pathology and Cytology, Global Hospitals, Hyderabad, Andhra Pradesh, India
2 Department of Nephrology, Gandhi Medical College, Secunderabad, Andhra Pradesh, India
3 Department of Nephrology, Global Hospitals, Hyderabad, Andhra Pradesh, India
4 Department of Nephrology, Hyderabad Kidney and Laparoscopic Centre, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Prof. S Radha
Plot No 20, House No 18, Alakapuri, Hyderabad - 35, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.137173

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Recurrence of FSGS in renal allo grafts is a major cause of graft loss. In this context, we tried to diagnose and classify FSGS in renal allografts. Indications for biopsy included graft dysfunction and/or proteinuria. Three hundred and sixty-three graft biopsies were studied over a period of 2 years. We classified FSGS into recurrent FSGS, new-onset primary FSGS and FSGS secondary to chronic humoral rejection, calcineurin inhibitor toxicity, and nephron loss and hyperfiltration injury. Twenty-four cases were diagnosed as FSGS, constituting 6.6%. Secondary FSGS was the most common FSGS in grafts in our study. Incidence of recurrent FSGS may not be accurate as pretransplant biopsy is available in very few cases.


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Indian Journal of Nephrology
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Online since 20th Sept '07