| REVIEW ARTICLE |
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| Year : 2015 | Volume
: 25
| Issue : 4 | Page : 189-193 |
Basics of base in hemodialysis solution: Dialysate buffer production, delivery and decontamination
N Desai
Department of Nephrology, Louis Stokes Veterans Affairs Medical Center, University Hospitals of Cleveland, Ohio, USA
Correspondence Address:
N Desai
Department of Nephrology, Room 2B-100L, 10701 East Blvd, Cleveland, 44106, Ohio
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0971-4065.147369
Hemodialysis requires the use of high volumes of freshly prepared, clean dialysate to foster the removal of low molecular weight metabolites (i.e., urea) and to correct the electrolyte and acid-base imbalance of chronic renal failure. Dialysate is produced by mixing clean, AAMI grade water with both an acid and base concentrate. This purpose of this report is to describe production, mixing and delivery of the buffer component of dialysate, and to also to address the cost, safety and feasibility of producing online bicarbonate. As endotoxin contaminated dialysate has been associated with the release of key mediators in acute and chronic inflammatory diseases associated with long-term hemodialysis therapy, aspects of disinfecting a bicarbonate delivery loop are also addressed.
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