Clinical significance of urinary liver-type fatty acid binding protein at various stages of nephropathy

V Viswanathan; S Sivakumar; V Sekar; D Umapathy; S Kumpatla

doi:10.4103/0971-4065.145097

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ORIGINAL ARTICLE

Year : 2015 | Volume : 25 | Issue : 5 | Page : 269-273

Clinical significance of urinary liver-type fatty acid binding protein at various stages of nephropathy

V Viswanathan¹, S Sivakumar², V Sekar², D Umapathy², S Kumpatla²
¹ Department of Diabetology, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Center (WHO Collaborating Center for Research Education and Training in Diabetes), Royapuram, Chennai, Tamil Nadu, India
² Department of Biochemistry and Molecular Genetics, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Center (WHO Collaborating Center for Research Education and Training in Diabetes), Royapuram, Chennai, Tamil Nadu, India

Correspondence Address:
V Viswanathan
M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Center (WHO Collaborating Center For Research Education and Training in Diabetes), Royapuram, Chennai - 600 013, Tamil Nadu
India

Source of Support: Prof. M. Viswanathan Diabetes Research Centre, Conflict of Interest: None

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DOI: 10.4103/0971-4065.145097

This cross-sectional study was to evaluate the levels of urinary liver-type fatty acid binding protein (u-LFABP pg/mg urine creatinine ratio) at different stages of diabetic nephropathy and to see its correlation with other clinical parameters in South Indian patients with type 2 diabetes mellitus (T2DM). A total of 65 (M: F; 42:23) T2DM subjects were divided into three groups, and were compared with 13 (M: F; 3:10) nondiabetic controls. The study groups were as follows: normoalbuminuric (n = 22), microalbuminuric (n = 22) and macroalbuminuric (n = 21). Estimated glomerular filtration rate (eGFR) was calculated using Cockcroft and Gault formula. u-LFABP levels in spot urine samples were measured with a solid phase enzyme linked immunosorbent assay. This study showed that u-LFABP levels were undetectable in healthy controls and was very low in the normoalbuminuric subjects. Elevated levels of u-LFABP are evident from the microalbuminuric stage indicating tubular damage. The levels of u-LFABP increased gradually with declining renal function. Geometric mean (95% confidence interval) for normoalbuminuria was 0.65 (0.47-0.97), microalbuminuria was 0.99 (0.55-1.97) and macroalbuminuria was 5.16 (1.8-14.5), (P = 0.005). In conclusion, u-LFABP levels were elevated in patients with reduced eGFR and showed a positive correlation with systolic blood pressure and protein to creatinine ratio in the total study subjects.

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