| CASE REPORT |
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| Year : 2017 | Volume
: 27
| Issue : 5 | Page : 406-409 |
Everolimus-associated acute kidney injury in patients with metastatic breast cancer
A Chandra1, NS Rao1, KP Malhotra2, M Rastogi3, R Khurana3
1 Department of Nephrology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Pathology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
3 Department of Radiation Oncology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Correspondence Address:
N S Rao
Department of Nephrology, Dr. RML Institute of Medical Sciences, Vibhuti Khand, Lucknow - 226 001, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijn.IJN_304_16
Recently, everolimus (Evl) has been introduced in the management of hormone receptor-positive metastatic breast cancer, in combination with aromatase inhibitors. Evl-induced acute kidney injury has hitherto been described in other malignancies, especially renal cell cancer, but only once before in a patient with breast cancer. We describe two cases of Evl-associated nephrotoxicity in patients with breast cancer, one of whom underwent a renal biopsy showing acute tubular necrosis. Both our patients improved after withdrawal of the offending agent and have normal renal functions on follow-up.
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