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 CASE REPORT
Year : 2017  |  Volume : 27  |  Issue : 5  |  Page : 406-409

Everolimus-associated acute kidney injury in patients with metastatic breast cancer


1 Department of Nephrology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Pathology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
3 Department of Radiation Oncology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
N S Rao
Department of Nephrology, Dr. RML Institute of Medical Sciences, Vibhuti Khand, Lucknow - 226 001, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijn.IJN_304_16

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Recently, everolimus (Evl) has been introduced in the management of hormone receptor-positive metastatic breast cancer, in combination with aromatase inhibitors. Evl-induced acute kidney injury has hitherto been described in other malignancies, especially renal cell cancer, but only once before in a patient with breast cancer. We describe two cases of Evl-associated nephrotoxicity in patients with breast cancer, one of whom underwent a renal biopsy showing acute tubular necrosis. Both our patients improved after withdrawal of the offending agent and have normal renal functions on follow-up.






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Indian Journal of Nephrology
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Online since 20th Sept '07