Indian Journal of Nephrology About us |  Subscription |  e-Alerts  | Feedback | Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Current Issue | Archives| Ahead of print | Search |Instructions |  Editorial Board  

Users Online:4171

Official publication of the Indian Society of Nephrology
 ~  Similar in PUBMED
 ~  Search Pubmed for
 ~  Search in Google Scholar for
 ~  Article in PDF (506 KB)
 ~  Citation Manager
 ~  Access Statistics
 ~  Reader Comments
 ~  Email Alert *
 ~  Add to My List *
* Registration required (free)  

   Article Figures

 Article Access Statistics
    PDF Downloaded110    
    Comments [Add]    

Recommend this journal


  Table of Contents  
Year : 2018  |  Volume : 28  |  Issue : 1  |  Page : 81-82

The role of renal angiography in Hepatitis B-related polyarteritis nodosa

1 Division of Nephrology and Hypertension, University of California San Diego, CA, USA
2 Division of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

Date of Web Publication13-Feb-2018

Correspondence Address:
Dr. R Malhotra
3350 La Jolla Village Drive, 9111H, San Diego, CA 92161-9111
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_82_17

Rights and Permissions

How to cite this article:
Malhotra R, Al Nimri O. The role of renal angiography in Hepatitis B-related polyarteritis nodosa. Indian J Nephrol 2018;28:81-2

How to cite this URL:
Malhotra R, Al Nimri O. The role of renal angiography in Hepatitis B-related polyarteritis nodosa. Indian J Nephrol [serial online] 2018 [cited 2022 Dec 5];28:81-2. Available from:

  Case Top

A 45-year-old female presented to our facility with a 3-month history of persistent headache and abdominal pain. She also complained of vertigo, blurred vision, and bilateral eye pain. She had a medical history significant for hypertension, hypothyroidism, and chronic Hepatitis B infection. Physical examination revealed blood pressure of 148/68 mmHg and pulse of 64/min, and diplopia was pronounced when looking to the right. Fundi were normal. Cardiovascular and respiratory system and abdominal examination were unremarkable. Computer tomographic (CT) scan of brain was normal. CT angiography of the head was negative for aneurysm or thrombus. Laboratory work was negative for complement levels, antinuclear antibody, anticardiolipin antibodies, and cryoglobulins. Hemoglobin and plasma biochemistry were normal. Erythrocyte sedimentation rate was elevated with a value of 60 mm/h and C-reactive protein of 15 mg/l. Urine microscopy was normal with no proteinuria. Hepatitis B surface antigen was positive and hepatitis B virus (HBV) DNA as detected by polymerase chain reaction revealed a viral load of more than 318,337 copy/ml. Renal angiogram, performed because of a suspicion of polyarteritis nodosa (PAN), showed multiple microaneurysms in the renal circulation [Figure 1]. The patient was started on steroid and tenofovir therapy with symptomatic improvement.
Figure 1: (a and b) Renal artery aneurysms

Click here to view

  Diagnosis Top

Patient was diagnosed as a case of Hepatitis B-related Polyarteritis Nodosa.

  Discussion Top

PAN is a systemic disease, characterized by panmural necrotizing vasculitis affecting small- and medium-sized arteries. PAN is more common in males between fifth and seventh decade. The etiology of PAN is largely unknown. HBV infection may play an important role in the disease pathogenesis by deposition of HBeAg/anti-HBe immune complexes in vessel walls resulting in focal inflammation.[1] The clinical spectrum of PAN ranges widely from mild forms with fever, malaise, arthralgias or arthritis, skin rash, neuritis to severe form with renal, or gastrointestinal involvement. Kidney is commonly involved in 70%–80% of cases of PAN with clinical manifestations ranging from malignant hypertension, proteinuria, renal insufficiency, or hemorrhage due to microaneurysms. However, occasionally, clinical features may be absent or exceedingly variable and thus making the diagnosis of PAN quite challenging. The tissue biopsy of symptomatic organ may provide definite diagnosis of PAN, but sampling errors and lack of disease specificity limit the value of biopsy. Studies have shown that angiography is a valuable diagnostic tool with a sensitivity of 89% and a specificity of 90% for PAN.[2] The most striking angiographic finding includes appearance of aneurysms, usually microaneurysms, ectasia, or occlusive disease. Spontaneous perinephric hematoma and retroperitoneal hemorrhage may result from a ruptured renal artery aneurysm and can be potentially fatal complication of PAN. Renal angiography should be considered in cases where PAN is suspected despite having stable and normal renal function.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Trepo C, Guillevin L. Polyarteritis nodosa and extrahepatic manifestations of HBV infection: The case against autoimmune intervention in pathogenesis. J Autoimmun 2001;16:269-74.  Back to cited text no. 1
Hekali P, Kajander H, Pajari R, Stenman S, Somer T. Diagnostic significance of angiographically observed visceral aneurysms with regard to polyarteritis nodosa. Acta Radiol 1991;32:143-8.  Back to cited text no. 2


  [Figure 1]


Print this article  Email this article


Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07