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Year : 2019  |  Volume : 29  |  Issue : 2  |  Page : 135-139

Bladder carcinoma associated with BK virus in a renal allograft recipient

Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India

Correspondence Address:
L Gaur
A-1102, Sunbreez Apartments, Sector-5, Vaishali, Ghaziabad - 201 010, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_434_17

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Bladder carcinoma is a relatively rare carcinoma reported in renal allograft recipients. While many oncogenic viruses have been implicated as causative factors for certain malignancies, questions have been raised about possible role of BK virus in pathogenesis of urothelial cancers. In this report, we have described a patient who developed BK virus nephropathy followed 3 years later by bladder carcinoma. Interestingly, while the tumor tissue demonstrated BK virus, the adjacent normal urothelium was stained negative for BK virus. Considering the viral potential to inhibit tumor suppressors and its differential localization within tumor tissue, it is possible that the virus contributes to tumorigenesis.


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Indian Journal of Nephrology
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Online since 20th Sept '07