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Year : 2020  |  Volume : 30  |  Issue : 3  |  Page : 204-206

Rare, yet emerging cause of graft dysfunction—ALECT 2 amyloidosis

1 Division of Nephrology, Grecian Hospital, Mohali, Punjab, India
2 Department of Histopathology, Core Diagnostics, Gurgaon, Haryana, India
3 Department of Histopathology, Medicos Centre, Chandigarh, India
4 Department of Transplant Surgery, Surya Kidney Hospital, Mohali, Punjab, India

Correspondence Address:
Dr. Kulwant Singh
Division of Nephrology, Grecian Hospital, Sector 69, Mohali - 160 062, Punjab
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_258_19

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Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. Amyloidosis derived from leukocyte cell-derived chemotaxin 2 (LECT2) is a recently recognized form of amyloidosis in the United States with predominant involvement of kidney and liver. We present a case of ALECT2 renal amyloid in a transplant recipient who presented with gradual worsening of graft function and subnephrotic proteinuria. To our knowledge, this is first case of LECT2 amyloidosis from Northern India in a transplant recipient. There is no effective therapy for amyloidosis derived from leukocyte cell-derived chemotaxin 2.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07