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Year : 2022  |  Volume : 32  |  Issue : 5  |  Page : 495-497

Post COVID vaccination (COVAXIN™ -BB152 V) pauci-immune crescentic glomerulonephritis

1 Department of Nephrology and Renal Transplant Medicine, Medanta -The Medicity, Gurugram, India
2 Department of Pathology and Laboratory Medicine, Medanta -The Medicity, Gurugram, India

Correspondence Address:
Abhyuday S Rana
Department of Nephrology and Renal Transplant Medicine, Medanta -The Medicity, Sector 38, Gurguram - 122001, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.ijn_352_21

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Coronavirus disease 2019 (COVID-19) pandemic is responsible for widespread morbidity and mortality. The vaccination against the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection, the cause of the COVID-19 pandemic, is currently ongoing across the globe. Rapid vaccination is of paramount importance to mitigate this pandemic. Although considered safe in general, these vaccines have their share of rare adverse events. We report a case of antineutrophil cytoplasmic antibody (ANCA)-associated pauci-immune crescentic glomerulonephritis 15 days post 2nd dose of a killed COVID-19 (COVAXIN™ -BB152 V) vaccine. We hypothesize that vaccination triggered a systemic immune response in a susceptible patient to develop ANCA-associated vasculitis (AAV), leading to rapidly progressive glomerulonephritis (RPGN).


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Indian Journal of Nephrology
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Online since 20th Sept '07