Advertisment

Indian Journal of Nephrology About us |  Subscription |  e-Alerts  | Feedback | Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Current Issue | Archives| Ahead of print | Search |Instructions |  Editorial Board  

Users Online:416

Official publication of the Indian Society of Nephrology
 ~   Next article
 ~   Previous article
 ~   Table of Contents

 ~   Similar in PUBMED
 ~  Search Pubmed for
 ~  Search in Google Scholar for
 ~Related articles
 ~   Citation Manager
 ~   Access Statistics
 ~   Reader Comments
 ~   Email Alert *
 ~   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed634    
    Printed19    
    Emailed0    
    PDF Downloaded48    
    Comments [Add]    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2022  |  Volume : 32  |  Issue : 6  |  Page : 606-610

Effect of dialyzer reuse on the activity of paraoxonase 1 in patients on hemodialysis


1 Department of Clinical Medicine, Post-Graduation Program in Health Sciences, Londrina State University (UEL), Paraná, Brazil
2 Department of Pathology, Clinical and Toxicological Analysis, Londrina State University (UEL), Paraná, Brazil
3 Department of Clinical Medicine, Discipline of Nephrology, Londrina State University (UEL), Paraná, Brazil

Correspondence Address:
Reynaldo Miguita Jr.
Clínica dos Rins Nefronor, Rua Nossa Senhora do Rocio, 154, Cornélio Procópio, Paraná, CEP86300-000
Brazil
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijn.IJN_77_21

Rights and Permissions

Background: Cardiovascular disease is the major cause of mortality in patients undergoing chronic hemodialysis treatment. The oxidative modification of low-density lipoprotein is a crucial step in the pathogenesis of atherosclerosis. Paraoxonase 1 (PON1) is the protein responsible for most of the antioxidant activity of high-density lipoprotein, and its reduced levels are associated with more cardiovascular events in several populations. In hemodialysis patients, reduced PON1 activity has been shown to be associated with increased cardiovascular mortality. Studies have shown that after the hemodialysis session, the activity of PON1 increases. The influence of dialyzer reuse on the activity of PON1 is unknown. We aimed to evaluate the effect of the reuse of two types of dialyzers (polynephron and polyethersulfone) on the PON1 activity of hemodialysis patients. Subjects and Methods: A total of 30 patients on hemodialysis were included. Pre- and post-dialysis blood samples were collected to analyze the activity of PON1 in the first use of the dialyzer and in the hemodialysis session of its sixth reuse. This process was carried out with polynephron (bisphenol-free) and polyethersulfone dialyzers. Results: We found that post-dialysis PON1 activity was significantly higher than pre-dialysis activity in both the first use and sixth reuse (P < 0.001). Conclusion: The practice of reusing the dialyzer did not interfere with the improvement of PON1 activity after the hemodialysis session.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07