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Author Reply
24 (
4
); 264-264
doi:
10.4103/0971-4065.133048

Author response on: Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy

Department of Medicine, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
Department of Nephrology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
Department of Rheumatology and Clinical Immunology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
Address for correspondence: Dr. Sumantro Mondal, Doctor's Hostel, 242 A.J.C. Bose Road, Kolkata - 700 020, West Bengal, India. E-mail: drmsumantro@gmail.com

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This article was originally published by Medknow Publications & Media Pvt Ltd and was migrated to Scientific Scholar after the change of Publisher.

Sir,

We appreciate the reference based comments of Dr. Nasri and thank him for his interest in our article.[1] The association of thrombotic microangiopathy (TMA) with IgA nephropathy, especially in patients with uncontrolled hypertension has been reflected in various studies. A study by Chang et al. found TMA in 10 patients with IgA nephropathy but three patients had only ultrastructural features of TMA.[2] Hence it is possible that TMA may be overlooked by light microscopy. Some patient may have near normal renal histology in the face of TMA.[3] Significant proteinuria, as seen in our patient is also strongly associated with TMA. However in our patient, there was no histological evidence of TMA. The renal Doppler study was also normal.[4] A study by Platt showed a significantly higher resistive index in nephropathies with tubulo-interstitial and/or vascular injury.[5] Due to lack of histological and Doppler evidence we could not comment about TMA in our patient. Though the significance of TMA as an etiological factor of hypertension in IgA nephropathy has been poorly understood, this finding should be actively searched for especially in patients with similar clinical phenotype.

References

  1. , , , , , , . Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy. Indian J Nephrol. 2013;23:390-2.
    [Google Scholar]
  2. , , , , , . A clinicopathologic study of thrombotic microangiopathy in the setting of IgA nephropathy. Clin Nephrol. 2006;66:397-404.
    [Google Scholar]
  3. , , , , , , . A clinicopathologic study of thrombotic microangiopathy in IgA nephropathy. J Am Soc Nephrol. 2012;23:137-48.
    [Google Scholar]
  4. , , , , , . Current role of color Doppler ultrasound in acute renal failure. Radiol Med. 2001;102:340-7.
    [Google Scholar]
  5. , . Duplex Doppler evaluation of native kidney dysfunction: Obstructive and nonobstructive disease. AJR Am J Roentgenol. 1992;158:1035-42.
    [Google Scholar]

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