Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Author Reply
Book Review
Brief Communication
Case Report
Case Series
Clinical Case Report
Clinicopathological Conference
Commentary
Corrigendum
Editorial
Editorial – World Kidney Day 2016
Editorial Commentary
Erratum
Foreward
Guidelines
Image in Nephrology
Images in Nephrology
Letter to Editor
Letter to the Editor
Letters to Editor
Literature Review
Notice of Retraction
Obituary
Original Article
Perspective
Research Letter
Retraction Notice
Review
Review Article
Short Review
Special Article
Special Feature
Special Feature - World Kidney Day
Systematic Review
Technical Note
Varia
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Author Reply
Book Review
Brief Communication
Case Report
Case Series
Clinical Case Report
Clinicopathological Conference
Commentary
Corrigendum
Editorial
Editorial – World Kidney Day 2016
Editorial Commentary
Erratum
Foreward
Guidelines
Image in Nephrology
Images in Nephrology
Letter to Editor
Letter to the Editor
Letters to Editor
Literature Review
Notice of Retraction
Obituary
Original Article
Perspective
Research Letter
Retraction Notice
Review
Review Article
Short Review
Special Article
Special Feature
Special Feature - World Kidney Day
Systematic Review
Technical Note
Varia
View/Download PDF

Translate this page into:

Letters to Editor
20 (
4
); 223-224
doi:
10.4103/0971-4065.73434

Onion-cadmium-renal function: Relationship?

Wiwanitkit House, Bangkhae, Bangkok – 10160, Thailand
Address for correspondence: Prof. Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok – 10160, Thailand. E-mail: wviroj@yahoo.com
Licence

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Disclaimer:
This article was originally published by Medknow Publications and was migrated to Scientific Scholar after the change of Publisher.

Sir,

I read the recent report by Ige et al, with a great interest.[1] Ige et al, concluded that “Cd exposure causes renal dysfunction, but oral administration of onion could prevent it.”[1] This animal model study is very interesting but further implication for clinical practice in human beings should be carefully done. First, the study on a few subjects in this work might have limitation in identification of toxicity and confirmation of effectiveness of the extract. Second, whether the extract process has any modification in biochemical and physical properties of active herbal gradients in onion is questionable. If there is any modification, the actual clinical use must be the extracted regimen not crude onion. Third, the metabolism of Cd is affected by cytochrome polymorphism.[2] There is no information on this aspect for studied subjects in the report by Ige et al.[1] Finally, if onion has actual pharmacological effect for the improvement of renal function, the exact dosage for human beings has to be further assessed.

References

  1. , , , , , , . Onion (Allium cepa) extract prevents cadmium induced renal dysfunction. Indian J Nephrol. 2009;19:140-4.
    [Google Scholar]
  2. , . Nephrotoxicity and the proximal tubule: Insights from cadmium. Nephron Physiol. 2003;93:87-93.
    [Google Scholar]

Fulltext Views
52

PDF downloads
42
View/Download PDF
Download Citations
BibTeX
RIS
Show Sections