Indian Journal of Nephrology About us |  Subscription |  e-Alerts  | Feedback | Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Current Issue | Archives| Ahead of print | Search |Instructions |  Editorial Board  

Users Online:1156

Official publication of the Indian Society of Nephrology
Ahead of Print

Renal hypouricemia with exercise induced acute kidney injury-A case report

1 Department of Nephrology, AINU, Hyderabad, Telangana, India
2 Department of Anesthesiology, Axon Group, Hyderabad, Telangana, India

Correspondence Address:
Srikanth Gundlapalli,
Consultant Nephrologist, Asian Institute of Nephrology and Urology, Erramanzil Colony, Somajiguda, Hyderabad - 500 082, Telangana
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_127_20

Acute kidney injury after exercise is most commonly secondary to rhabdomyolysis. Non-rhabdomyolysis AKI is secondary to a limited number of disorders of which renal hypouricemia (RHUC) needs a special mention. It is relatively a rare genetic disorder and is reported in Japanese and Ashkenazi Jews. Humans have lost the ability to metabolize uric acid as the “uricase” gene is suppressed. Renal tubules handle uric acid and aid in maintaining serum concentrations in the soluble range. Uric acid excretion is increased in RHUC patients due to proximal tubular defects. This leads to the loss of antioxidant capabilities of the kidney, predisposing them to severe AKI following anaerobic exercise. We report a case of exercise-induced AKI secondary to renal hypouricemia.

Print this article
  Search Pubmed for
    -  Gundlapalli S
    -  Gaur Y
    -  Rao M V
    -  Bande SR
    -  Sandhya P
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded12    

Recommend this journal

Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07