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Official publication of the Indian Society of Nephrology
 
ORIGINAL ARTICLE
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Spot urine albumin creatinine ratio can be a predictor of cognitive function in type 2 diabetes mellitus


 Department of Medicine, Lady Hardinge Medical College and SSK Hospital, New Delhi, India

Correspondence Address:
Deepak Kumar Panigrahi,
A21, Shree Balaji Apartments, Plot 37, Sector 6, Dwarka, New Delhi - 110075
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_286_20

Introduction: In diabetes mellitus (DM), the underlying pathophysiology of albuminuria and cognitive dysfunction is similar. So, we hypothesized that urinary albumin excretion (UAE) could be linked to cognitive dysfunction in type 2 diabetes mellitus. Methods and Materials: It was a hospital-based observational study. Patient aged 40–60 years with type 2 DM were included in this study. Complete assessment with detailed history, physical examination, and necessary biochemical investigations including spot urine albumin creatinine ratio (uACR) was done. Cognitive status was determined in all the individuals with the application of Hindi translated version of the mini-mental status examination (MMSE) questionnaire. Results: In 80 patients, the mean MMSE score was 25.37 ± 3.34. Cognitive dysfunction (score <26) was present in 45% of individuals. Spot uACR, estimated glomerular filtration rate (eGFR), glycated hemoglobin (HbA1c), presence of retinopathy and dyslipidemia were significantly different between the normal and subnormal scoring groups. On multivariate analysis spot uACR was found to be independently predicting odds of developing cognitive dysfunction (OR 1.01, CI 1.004–1.022; P = 0.001).The mean MMSE scores in normo-albuminuric (n = 15), moderately increased albuminuric (n = 48) and severely albuminuric (n = 17) patients were 28.00 ± 1.60, 25.54 ± 3.33 and 22.58 ± 2.31, respectively, which were significantly different among the three groups (P < 0.001). Conclusions: Spot uACR could be helpful in predicting cognitive decline in people with type 2 DM.


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    -  Panigrahi DK
    -  Chaudhury D
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Indian Journal of Nephrology
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Online since 20th Sept '07