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Official publication of the Indian Society of Nephrology
 
CASE REPORT
Ahead of Print

Complete Remission of Lupus Nephritis Following Chemoradiotherapy of Carcinoma Cervix: An Association


1 Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
3 Department of Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Manish Rathi,
Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_267_20

Systemic lupus erythematosus (SLE) is associated with a higher incidence of solid organ malignancies, including cervical carcinoma, creating a paradox in their management in the context of autoimmunity. We present a case of 45-year-old female presented with mucocutaneous, musculoskeletal symptoms of SLE. Renal biopsy showed class IV lupus nephritis (LN); modified NIH activity score: 8/24, chronicity score: 6/12. Post NIH regimen induction, she achieved partial remission; further developed proteinuric relapse which was re-induced with mycophenolate mofetil (MMF) to which she failed to respond. Subsequently diagnosed with carcinoma cervix stage IIB, she received four cycles of concurrent cisplatin-based chemoradiotherapy. MMF was stopped; low dose steroids continued. Following this, the patient achieved complete remission (CR) of LN and is in remission for 5 years. This is an unexpected association between chemoradiotherapy of cervical carcinoma and CR of class IV LN, allowing long-term discontinuation of immunosuppression.


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