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Official publication of the Indian Society of Nephrology
 
ORIGINAL ARTICLE
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Relation between vitamin d level and cyclin-dependent kinase-1 gene expression in egyptian patients with lupus nephritis and their impact on disease activity


1 Department of Immunology and Allergy Medical Research Institute, Alexandria University, Alexandria, Egypt
2 Internal Medicine, Medical Research Institute, Alexandria University, Alexandria, Egypt
3 National Blood Transfusion Center, Iraq Ministry of Health, Baghdad, Iraq, Egypt
4 Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt

Correspondence Address:
Dalia A Maharem,
21 Rayad Street, El Fagr Tower, Zeizenia, Alexandria
Egypt
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_359_19

Introduction: Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. Vitamin D and cycline-dependent kinase-1 (CDK1) have been implicated in its pathogenesis. The aim of this study was to determine the relation between vitamin D level and CDK-1 in lupus nephritis patients and their impact on disease activity. Patients and Methods: The current study was conducted on 50 LN patients and 20 control subjects from Egyptian population using ELISA to assess vitamin D level in serum and TaqMan assay for CDK1 gene expression. Results: Serum vitamin D level was significantly lower in LN patients and CDK-1 gene was down expressed in the majority of LN patients. A significant inverse correlation was found between vitamin D level and 24 h protein in urine, ANA, anti-dsDNA, CRP, with a significant positive correlation with renal biopsy indices, eGFR. There was a non-significant inverse correlation between vitamin D and CDK-1 (before RO-3306 addition) and a positive correlation after RO-3306. A significant positive correlation was found between CDK-1 gene expressions with urinary albumin/creatinine ratio. However, a significant positive correlation was found between CDK-1 (after RO-3306 addition) and proteinuria. While a significant positive correlation was found between CDK-1 expression (after RO-3306 addition) and ANA, a significant positive correlation was found between CDK-1 expression (before RO-3306 addition) and anti-dsDNA but CDK-1 is not associated with renal biopsy indices nor with activity indices of SLE. There was a positive correlation between CDK-1 gene expression and CRP before and after RO-3306 addition. Conclusions: Vitamin D deficiency acts as a risk factor for developing LN. CDK-1 may have an association with the diagnosis of LN but its association with the progression of staging of LN is still confusing


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    -  Osman EM
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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07