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Official publication of the Indian Society of Nephrology
 
ORIGINAL ARTICLE
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Comparative analysis between urinary calprotectin and serum creatinine for early detection of intrinsic acute kidney injury


1 Pediatric Nephrologist, Department of Pediatric Nephrology, Imam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran
2 Associated Professor of Pediatric Nephrology, Pediatric Chronic Kidney Diseases Research Center, Pediatric Center of Excellence, Tehran University of Medical Science, Tehran, Iran
3 Professor of Pediatric Nephrology, Pediatric Center of Excellence, Tehran University of Medical Science, Tehran, Iran
4 Fellowship of NICU, Children Medical Center Hospital, Tehran University of Medical Science, Tehran, Iran
5 Associated Professor of Pediatric nephrology, Pediatric Chronic Kidney Disease Research Center, Pediatric Center of Excellence, Tehran University of Medical Science, Tehran, Iran

Correspondence Address:
Mastaneh Moghtaderi,
Associate Professor of Pediatric Nephrology Mailing Address: Pediatric Chronic Kidney Diseases Research Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Dr. Qarib St. Tehran
Iran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_83_20

Background: Acute kidney injury (AKI) is a common and important clinical condition that may lead to chronic kidney disease if it is not diagnosed and treated in its early stages. Urinary calprotectin is a valuable recognized biomarker that can be used to differentiate prerenal and intrinsic AKI. However, till date only a few reports on urine calprotectin measurement in early diagnosis of intrinsic AKI are available. In this study, we compared the sensitivity and specificity of urinary calprotectin with those of serum creatinine in detecting early intrinsic AKI. Methods: Over 6 months period (April to October 2018), 81 of 408 patients admitted to the pediatric intensive care unit met the criteria of this cross-sectional study. Their serum creatinine and urinary calprotectin were measured on the first and third day of admission using Jaffe and Elisa radioimmunoassay methods, respectively. The AKI was defined according to the pRIFLE criteria. Results: Of the total 81 patients, 67 had the criteria of intrinsic AKI. Of these 62% were female and 38% were male. The mean age of the patients was 22 months. According to data analysis, the area under the curve of ROC of urinary calprotectin on day-1 to detect renal failure is 0.93 with the best cutoff point obtained at 530 ng/mL. The sensitivity, specificity, positive, and negative predictive values of urinary calprotectin levels in diagnosing AKI at this cutoff point are 92.5%, 92.8%, 98.4, and 72.2%, respectively. Besides, urinary calprotectin changes occur much earlier than the rising of serum creatinine. Conclusion: Urinary level of calprotectin is a very sensitive biomarker for early diagnosis of intrinsic AKI in children and it can be used in intensive care units or anywhere critically ill children admitted to detect intrinsic AKI. Besides, this study shows that urine calprotectin may be a more sensitive and specific biomarker than serum creatinine in the early phases of intrinsic AKI.


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Indian Journal of Nephrology
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Online since 20th Sept '07