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Rare case report of de-novo pauci-immune necrotizing crescentic glomerulonephritis in 1st-week post-kidney transplantation

 Department of Nephrology, Manipal Hospitals, Bengaluru, Karnataka, India

Correspondence Address:
Deepesh Vellakampadi,
B-912, Brigade Omega, Bengaluru - 560 061, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_405_19

Early post-transplant de-novo pauci-immune necrotizing crescentic glomerulonephritis occurring within the first week post transplantation has not been reported according to the literature search done by us. Here, we are reporting a 56 years male patient who underwent living spousal donor kidney transplantation for presumed diabetic nephropathy, and developed pauci-immune necrotizing crescentic glomerulonephritis (NCGN) on sixth day post-transplant. Post-renal transplant recurrence of disease in ANCA-associated vasculitis patients occurs within days to months. However, development of de-novo pauci-immune crescentic glomerulonephritis is a rare occurrence. We report this patient who developed probable pauci-immune de-novo NCGN which responded to treatment with plasmapheresis, steroids and cyclophosphamide.

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Indian Journal of Nephrology
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Online since 20th Sept '07