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Successful treatment of severe heart failure in advanced diabetic kidney disease using angiotensin–neprilysin inhibitors (sacubitril/valsartan) – report of two cases with review of options in literature

1 Department of Nephrology, Virinchi Hospital, Banjara Hills, Hyderabad, Telangana, India
2 Department of Cardiology, Virinchi Hospital, Banjara Hills, Hyderabad, Telangana, India

Correspondence Address:
Ratan Jha,
Department of Nephrology, Virinchi HospitaL, Road No. 1, Banjara Hills, Hyderabad - 500 034, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_298_20

Patients with heart failure (HF) and advanced chronic kidney disease (CKD) constitute a special population that experience poor outcomes due to poor adherence to established therapies because of potential safety concerns. Role of newer agents like angiotensin–receptor neprilysin inhibitors (ARNI) in early stages of CKD is well elucidated. We report two cases of HF with reduced ejection fraction, who received ARNI in advanced stage of CKD (stage 5) and achieved remarkable outcomes in terms of quality of life and longevity.

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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07