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Official publication of the Indian Society of Nephrology
 
CASE REPORT
Ahead of Print

An unusual clinical manifestation of plasmablastic lymphoma in a renal transplant recipient


1 Department of Laboratory Science and Molecular Medicine, Army Hospital (Research and Referral), New Delhi, India
2 Department of Nephrology, Army Hospital (Research and Referral), New Delhi, India

Correspondence Address:
Devika Gupta,
Department of Laboratory Science and Molecular Medicine, Army Hospital (Research and Referral), New Delhi
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_23_20

Plasmablastic lymphoma is a rapidly progressive CD20 negative large cell non-Hodgkin lymphoma with poor outcome. It occurs mostly in immunocompromised individuals and has a predilection for extranodal sites. They need to be differentiated from other entities sharing similar morphological features like poorly differentiated carcinoma, Burkitt's lymphoma, Alk positive large B cell lymphoma, Diffuse large B cell lymphoma, and anaplastic myeloma. EBV negativity in recipients, type, intensity, and duration of immunosuppressives used are certain risk factors in development of posttransplant lymphoproliferative disorders. High index of suspicion can help clinch the diagnosis early and prevent catastrophic consequences. Our renal transplant recipient presented with complaints of pain abdomen and malena for which he underwent exploratory laparotomy. Diagnosis was established on histopathology and timely treatment initiated reverted the disease.


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Indian Journal of Nephrology
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Online since 20th Sept '07