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TAFRO syndrome treated effectively with corticosteroids: A case report and review of the literature

 Department of Internal Medicine, Faculty of Medicine, Akdeniz University, Antalya, Turkey

Correspondence Address:
Hasan Sozel,
Department of Internal Medicine, Faculty of Medicine, Akdeniz University, Antalya
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_520_20

TAFRO (thrombocytopenia, anasarca, fever, renal dysfunction, and organomegaly) syndrome is a subtype of Castleman's disease and has been described in recent years. In this case, a middle-aged woman was admitted to our clinic with a 2-week history of fever, weakness, cough, shortness of breath and edema all over the body. Physical examination on admission revealed pale conjunctiva, tachycardia, coarse crackles over left lower lung fields, pitting edema in the extremities, tense ascites, axillar, and bilateral inguinal lymph nodes measuring less than 2 cm. Inguinal lymph node excisional biopsy was compatible with TAFRO syndrome. We started corticosteroid treatment. The patient's general condition and physical findings improved. Laboratory values returned to normal limits. This case will help understand the clinical course and treatment strategy in TAFRO syndrome.

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Indian Journal of Nephrology
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Online since 20th Sept '07