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Official publication of the Indian Society of Nephrology
 
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Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?


 Department of Nephrology, Venkateshwar Hospital, Dwarka, New Delhi, India

Correspondence Address:
Prem P Varma,
A – 12, Third Floor, Sarvodaya Enclave, New Delhi - 110 017
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_330_20

Most cases of Baclofen toxicity have been reported in patients with impaired kidney functions, within a few days to weeks after ingestion. We report three cases of Baclofen induced encephalopathy in chronic kidney disease patients; two developed encephalopathy within 6–8 h after ingestion of a single tablet and third on 4th day of consuming 2.5 mg twice daily dose. All three cases recovered fully following haemodialysis treatment.


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    -  Varma PP
    -  Bajpai G
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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07