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COVID-19 in renal transplant recipients – A single center experience from India

 Department of Nephrology, Medanta Institute of Kidney and Urology, Medanta – The Medicity, Gurugram, Haryana, India

Correspondence Address:
Pranaw Kumar Jha,
Associate Director - Nephrology and Kidney Transplant Medicine, Department of Nephrology, Medanta – The Medicity, Sector-38, Gurugram, Haryana - 122 001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_479_20

Introduction: The information on the clinical outcome of renal transplant recipients getting COVID-19 infection is sparse. The aim of this study is to report a single-center experience of renal transplant recipients with COVID-19 from India. Methods: This was a retrospective study of 23 consecutive renal transplant recipients with COVID-19 infection presenting to our center from May 2020 to August 2020. Clinical parameters, laboratory values, imaging characteristics, and outcome of the patients were collected and analyzed. Results: Median follow-up duration was 36 (range: 10–110) days. Median age of patients was 54 (23–70) years, and 87% were male. Median duration since transplant was 69 (range: 15–132) months. The most common presenting feature was fever (82.6%), followed by breathlessness (43.5%) and cough (30.4%). Hospitalization rate was 52.2%, while 34.8% required ICU care. Severe to critical disease was seen in 39.1% of patients, and 17.4% required mechanical ventilation. Patients with severe disease had a higher incidence of lymphopenia (P = 0.005) when compared to the ones with mild to moderate disease. Acute kidney injury was seen in 39.1% of patients, and 13% required dialysis. Mortality rate was 13% overall, and 25% in those hospitalized. Conclusion: Renal transplant recipients with COVID-19 have a poor outcome. Although not all of them need hospitalization, they should be monitored closely. Immunosuppression minimization is an important part of the treatment strategy.

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