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Impact of kidney donation on pregnancy outcomes: A retrospective analysis
Anupma Kaul1, Dharmendra Bhaduaria1, Monika Yachha1, Manas Ranjan Behera1, Ravi Kushwaha1, Narayan Prasad1, Manas Ranjan Patel1, Aneesh Srivastava2
1 Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, Uttar Pradesh, India
2 Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, Uttar Pradesh, India
Correspondence Address:
Anupma Kaul,
Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ijn.ijn_411_21
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Introduction: Recent data suggest a risk of gestational hypertension, proteinuria and pre-eclampsia among pregnancies after kidney donation. Methods: This retrospective study among females who donated kidneys (1997–2017) at a tertiary renal transplant center in Northern India assessed the maternal and fetal outcomes of their pregnancy. Data of participants were collected using pre-tested semi structured questionnaire. Results: In total, 925 female kidney donors (1332 pregnancies) in the pre-donation group and 45 females (48 pregnancies) in the post donation period were included. The mean age of first pregnancy, weight (kg) gain, proportion of history of pre-natal check-up, institutional delivery, and history of unrelated donation was statically significant among the post-donation group. The proportion of pre-eclampsia, gestational hypertension, gestational diabetes, and post-partum hemorrhage was insignificantly higher among the post-donation group with higher preterm birth with low-birth-weight babies. Proteinuria (P < 0.05) was significantly higher among post donation pregnancies. In multivariate analysis, cesarean delivery and low birth weight (<2500 g) were common among the post-donation pregnancy group. Conclusions: The study demonstrated no significant risk to maternal outcomes butan increased risk to fetal outcomes in terms of prematurity and low birth weight among the post-donation pregnancy group.
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