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Official publication of the Indian Society of Nephrology
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Postpartum pulmonary-renal syndrome with thrombotic microangiopathy in systemic lupus erythematosus

1 Department of Nephrology, Command Hospital Air Force Bangalore, Bengaluru, Karnataka, India
2 Department of Rheumatology, Command Hospital Air Force Bangalore, Bengaluru, Karnataka, India
3 Department of Medicine, Medical Division, Command Hospital Air Force (CHAF), Bengaluru, Karnataka, India

Correspondence Address:
Vijoy Kumar Jha,
Department of Nephrology, Command Hospital Air Force Bangalore, Post Agram, Old Airport Road, Bengaluru 560 007, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.ijn_78_22

Postpartum pulmonary syndrome as lupus flares in inactive or mild lupus is uncommon. The diagnosis and management of postpartum lupus flare in second pregnancy presenting with crescentic lupus nephritis (LN), secondary thrombotic microangiopathy (TMA), and severe lupus vasculitis in an undiagnosed systemic lupus erythematosus is extremely challenging. Here, in this case report, we present a young lady who presented with postpartum acute kidney injury (AKI) with systemic complaints about 4 weeks post-term uneventful delivery. Renal biopsy was suggestive of crescentic LN with severe lupus vasculitis. The stormy course was further complicated with diffuse alveolar hemorrhage, portal venous thrombosis, TMA, and anuric AKI requiring renal replacement therapy. She received multiple sessions of plasmapheresis, steroid, intravenous immunoglobulin, inj. cyclophosphamide, and started showing improvement after about 6 weeks of presentation.

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Indian Journal of Nephrology
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Online since 20th Sept '07