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Management of antineutrophil cytoplasmic antibody–Associated vasculitis with COVID-19: A single center experience


 Nephrology Division, Superspeciality Hospital, Government Medical College, Srinagar, Jammu and Kashmir, India

Correspondence Address:
Muzamil Latief,
2nd Floor Dialysis Unit, Superspeciality Hospital Shireenbagh, Government Medical College, Srinagar - 190 010, Jammu and Kashmir
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.ijn_423_21

Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) patients particularly presenting as rapidly progressive glomerulonephritis (RPGN) are at extremely high risk of progressing to end-stage kidney disease (ESKD); therefore, timely intervention is important. We describe our experience of managing six AAV patients who were on treatment (induction phase) and developed COVID-19. Cyclophosphamide was stopped till RT-PCR for SARS-CoV-2 was reported negative and patient had improved symptomatically. Out of our six patients, one died. Subsequently, cyclophosphamide was successfully resumed in all the surviving patients. In patients of AAV with COVID-19, close monitoring and withholding of cytotoxic medication and continuing steroids till active infection subsides is an effective treatment strategy until more and more data from well-conducted largescale studies become available for guidance.


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    -  Latief M
    -  Mir TH
    -  Wani ML
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Indian Journal of Nephrology
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