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Official publication of the Indian Society of Nephrology
 
CASE REPORT
Ahead of Print

Successful renal transplant in castleman disease - First case report from India


1 Department of Nephrology, Apollo Health City, Hyderabad, Telangana, India
2 Department of Pathology, Apollo Health City, Hyderabad, Telangana, India

Correspondence Address:
Sanjay Maitra,
Flat No. 203, Uma Banjara, Road No. 13, Banjara Hills, Hyderabad - 500 034, Telangana
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.ijn_500_21

Castleman disease (CD) comprises a rare group of heterogenous benign lymphoproliferative disorders with pathologic similarities. However, they present with diverse clinical manifestations. Renal involvement is rare in CD and is mainly reported with plasma cell type of multicentric disease. Various glomerular pathologies, interstitial involvement, or thrombotic microangiopathies have all been reported, some of which progress to end-stage renal disease (ESRD). Progression of CD to ESRD is well documented; however, a patient on dialysis developing CD is rare. Moreover, kidney transplantations have seldom been performed on patients with CD. We report a patient with ESRD of unknown etiology who developed multicentric CD while on dialysis. He was treated with four doses of rituximab and later underwent a living kidney transplant with his wife as a donor. He has been clinically well ever since. We believe that this is possibly the first successful case of renal transplantation in CD with ESRD being reported from India.


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Indian Journal of Nephrology
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