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Year : 2008  |  Volume : 18  |  Issue : 1  |  Page : 28--29

Severe rhabdomyolysis and acute renal failure secondary to the use of simvastatin in undiagnosed hypothyroidism

FA Qari 
 Department of Nephrology, King Abdulaziz University, P. O. Box 80215, Jeddah 21589, Saudi Arabia

Correspondence Address:
F A Qari
King Abdulaziz University, P. O. Box 80215, Jeddah 21589
Saudi Arabia

A 52-year-old Indian woman with underlying diabetes mellitus, hyperlipidemia and undiagnosed hypothyroidism presented with generalized musculoskeletal pain and oliguria for three days. The patient was taking 80 mg of simvastatin (initiated 20 days before) after cardiac catheterization for an inferior myocardial infarction. Laboratory evaluation revealed the following serum levels: creatine kinase, 81,660 U/L; aspartate aminotransferase, 2,497 U/L; alanine aminotransferase, 1,304 U/L; blood urea nitrogen, 88 mg/dL; creatinine, 5.1 mg/dL; free thyroxine (FT 4 ), 12.6 Pmol/L and thyroid stimulating hormone, 22.7 uIU/L. Simvastatin was discontinued and the patient was administered forced alkaline diuresis. Her hypothyroidism was treated with thyroxine, which was continued after discharge. Her renal function recovered within two months. This case report discusses the higher incidence of rhabdomyolysis in patients with undiagnosed hypothyroidism receiving large doses of simvastatin.

How to cite this article:
Qari F A. Severe rhabdomyolysis and acute renal failure secondary to the use of simvastatin in undiagnosed hypothyroidism.Indian J Nephrol 2008;18:28-29

How to cite this URL:
Qari F A. Severe rhabdomyolysis and acute renal failure secondary to the use of simvastatin in undiagnosed hypothyroidism. Indian J Nephrol [serial online] 2008 [cited 2021 Dec 1 ];18:28-29
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2008;volume=18;issue=1;spage=28;epage=29;aulast=Qari;type=0