Indian Journal of Nephrology Home 

CASE REPORT
[View FULLTEXT] [Download PDF]
Year : 2015  |  Volume : 25  |  Issue : 2  |  Page : 113--116

Immunoglobulin G4-related tubulointerstitial nephritis associated with interstitial pulmonary disease: Report of a case with review of literature

M Saravanan1, S Alexander1, SM Matthai2, A Korula3, S Varughese1, V Tamilarasi1 
1 Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India
2 Department of Central Electron Microscopic Unit, Christian Medical College, Vellore, Tamil Nadu, India
3 Department of General Pathology, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Dr. S Alexander
Department of Nephrology, Christian Medical College, Ida Scudder Road, Vellore - 632 004, Tamil Nadu
India

Immunoglobulin G4-related disease (IgG4-RD) is an emerging clinicopathological entity. Renal involvement is dominated by tubulointerstitial nephritis (TIN) with IgG4-positive plasma cells and fibrosis. IgG4-RD commonly affects middle-aged to elderly men with accompanying extra-renal lesions such as sialadenitis, lymphadenopathy, or type 1 autoimmune pancreatitis, all of which respond favorably to corticosteroid therapy. The disease burden of IgG4-related kidney disease (IgG4-RKD) in India remains largely underestimated. We report a case of IgG4-RKD manifesting as TIN associated with interstitial pulmonary disease, illustrating typical clinico-pathologic, serologic, immuno-histochemical, and ultrastructural features of this condition. In view of potential amelioration of renal dysfunction with appropriate therapy, the need for awareness of this condition and early diagnosis is highlighted.

How to cite this article:
Saravanan M, Alexander S, Matthai S M, Korula A, Varughese S, Tamilarasi V. Immunoglobulin G4-related tubulointerstitial nephritis associated with interstitial pulmonary disease: Report of a case with review of literature.Indian J Nephrol 2015;25:113-116

How to cite this URL:
Saravanan M, Alexander S, Matthai S M, Korula A, Varughese S, Tamilarasi V. Immunoglobulin G4-related tubulointerstitial nephritis associated with interstitial pulmonary disease: Report of a case with review of literature. Indian J Nephrol [serial online] 2015 [cited 2022 Sep 26 ];25:113-116
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2015;volume=25;issue=2;spage=113;epage=116;aulast=Saravanan;type=0