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Year : 2017  |  Volume : 27  |  Issue : 5  |  Page : 406--409

Everolimus-associated acute kidney injury in patients with metastatic breast cancer

A Chandra1, NS Rao1, KP Malhotra2, M Rastogi3, R Khurana3 
1 Department of Nephrology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Pathology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
3 Department of Radiation Oncology, Dr. RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
N S Rao
Department of Nephrology, Dr. RML Institute of Medical Sciences, Vibhuti Khand, Lucknow - 226 001, Uttar Pradesh
India

Recently, everolimus (Evl) has been introduced in the management of hormone receptor-positive metastatic breast cancer, in combination with aromatase inhibitors. Evl-induced acute kidney injury has hitherto been described in other malignancies, especially renal cell cancer, but only once before in a patient with breast cancer. We describe two cases of Evl-associated nephrotoxicity in patients with breast cancer, one of whom underwent a renal biopsy showing acute tubular necrosis. Both our patients improved after withdrawal of the offending agent and have normal renal functions on follow-up.

How to cite this article:
Chandra A, Rao N S, Malhotra K P, Rastogi M, Khurana R. Everolimus-associated acute kidney injury in patients with metastatic breast cancer.Indian J Nephrol 2017;27:406-409

How to cite this URL:
Chandra A, Rao N S, Malhotra K P, Rastogi M, Khurana R. Everolimus-associated acute kidney injury in patients with metastatic breast cancer. Indian J Nephrol [serial online] 2017 [cited 2022 Jul 1 ];27:406-409
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2017;volume=27;issue=5;spage=406;epage=409;aulast=Chandra;type=0