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Year : 2020  |  Volume : 30  |  Issue : 2  |  Page : 110--112

A rare cause of coagulopathy in a patient with rapidly progressive renal failure

Rudreshwar Prabakaran1, Jasmine Sethi1, Manish Rathi1, Harbir Singh Kohli1, Pankaj Malhotra2, Krishan Lal Gupta1 
1 Department of Nephrology, PGIMER, Chandigarh, India
2 Department of Internal Medicine, PGIMER, Chandigarh, India

Correspondence Address:
Krishan Lal Gupta
Department of Nephrology, PGIMER, Chandigarh
India

Deranged coagulogram is a common problem, which a nephrologist faces before doing a renal biopsy. We describe a rare cause of coagulopathy in a patient with rapidly progressive renal failure due to acquired factor X deficiency caused by systemic light chain amyloidosis (AL). The patient had prolonged prothrombin and activated partial thromboplastin time, which got corrected on mixing with normal plasma, and factor X activity was markedly reduced at 5%. Rectal biopsy and immunofixation electrophoresis established the diagnosis of AL and the patient was started on bortezomib-based chemotherapy. Hence, appropriate coagulation work-up should be conducted in patients with renal dysfunction with prolonged coagulation times, as it can sometimes reveal the underlying diagnosis in situations where renal biopsy could not be done due to high risk of bleeding.

How to cite this article:
Prabakaran R, Sethi J, Rathi M, Kohli HS, Malhotra P, Gupta KL. A rare cause of coagulopathy in a patient with rapidly progressive renal failure.Indian J Nephrol 2020;30:110-112

How to cite this URL:
Prabakaran R, Sethi J, Rathi M, Kohli HS, Malhotra P, Gupta KL. A rare cause of coagulopathy in a patient with rapidly progressive renal failure. Indian J Nephrol [serial online] 2020 [cited 2021 Jan 18 ];30:110-112
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2020;volume=30;issue=2;spage=110;epage=112;aulast=Prabakaran;type=0