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Year : 2021  |  Volume : 31  |  Issue : 2  |  Page : 135--141

Delayed gastric emptying among Indian patients with non-diabetic chronic kidney disease

Madapathi Sampath Kumar1, Kolar Vishwanath Vinod1, Nandini Pandit2, Vivek Kumar Sharma3, Halanaik Dhanapathi2, Sreejith Parameswaran4 
1 Department of General Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantrinagar, Puducherry, India
2 Department of Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantrinagar, Puducherry, India
3 Department of Physiology, Government Institute of Medical Sciences, Greater Noida, Gautam Buddha University, Uttar Pradesh, India
4 Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantrinagar, Puducherry, India

Correspondence Address:
Dr. Kolar Vishwanath Vinod
Additional Professor, Department of General Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantri Nagar, Pondicherry - 605 006
India

Introduction: Upper gastrointestinal symptoms such as nausea, vomiting, abdominal bloating, and poor appetite are more frequent among chronic kidney disease (CKD) patients and may contribute to poor nutritional intake and malnutrition. Delayed gastric emptying (GE), one of the important contributors to these symptoms, has not been evaluated systematically in different stages of non-diabetic CKD, among Indian patients. Materials and Methods: This hospital-based, cross-sectional analytical study aimed to find out the frequency of delayed GE in non-diabetic CKD (stages: 3,4,5) patients and also to study the correlation between delayed GE and symptoms of gastroparesis, autonomic neuropathy and nutritional parameters. Patients were subjected to evaluation of symptoms of gastroparesis by standardized questionnaire (gastroparesis cardinal symptom index), nutritional status (by anthropometric measures and serum albumin), autonomic function by heart rate variability (HRV) and GE by gastric scintigraphy with a standardized solid rice idli (savory cake) meal labeled with technetium-99m sulfur colloid. Results: Of the 89 non-diabetic CKD (stages-3,4,5) patients evaluated, 22 (≈25%) had delayed GE and 8 (≈9%) rapid GE. Prevalence of delayed GE was higher among stage 5 (15/49, 31%) compared to stages 3 and 4 (7/40, 17.5%), though the difference was statistically insignificant. There was no association between delayed GE and symptoms of gastroparesis and autonomic neuropathy. Though not statistically significant, nutritional parameters (body mass index, skinfold thickness, and serum albumin) were poorer in the delayed GE group compared to the rest. Conclusion: Delayed GE, irrespective of symptoms, may contribute to malnutrition and hence should be looked for in non-diabetic CKD patients with unexplained malnutrition.

How to cite this article:
Kumar MS, Vinod KV, Pandit N, Sharma VK, Dhanapathi H, Parameswaran S. Delayed gastric emptying among Indian patients with non-diabetic chronic kidney disease.Indian J Nephrol 2021;31:135-141

How to cite this URL:
Kumar MS, Vinod KV, Pandit N, Sharma VK, Dhanapathi H, Parameswaran S. Delayed gastric emptying among Indian patients with non-diabetic chronic kidney disease. Indian J Nephrol [serial online] 2021 [cited 2022 Jan 22 ];31:135-141
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=2;spage=135;epage=141;aulast=Kumar;type=0